The church was inspired by the Byzantine tradition and built on the plan of a Greek cross, surmounted by a light-blue coloured dome and four smaller domes in the corners. The exterior is decorated with mosaics, alternated with marble and coloured stone.
The interior is characterized by frescoes and precious paintings, together with a solid wood iconostasis that separates the presbytery and is the keeper of very valuable icons.
The Church contains a silver candelabra donated by the future Tsar, Paul I, during a visit to Trieste in 1772.